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臍帶膜幹細胞的

潛在應用

研究人員認為臍帶內膜還含有其他類型的幹細胞，

這些幹細胞可能有用，但尚未被發現。

間質幹細胞臨床研究
上皮幹細胞臨床研究
價格詳情
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潛在的治療應用

時至今日，已經有超過10001項臨床試驗發掘間質幹細胞的潛力，至今試驗結果令人鼓舞。幹細胞療法已被證實安全及有效修復由中風及心臟病造成的損傷。間質幹細胞也可結合造血幹細胞進行治療，幫助加快造血幹細胞植入，並減少移植時出現免疫系統併發症2。

雖然有證據顯示間質幹細胞可分化成某些上皮細胞（非幹細胞），但間質幹細胞絕不可能轉化成上皮幹細胞。上皮幹細胞和上皮細胞的分別，在於上皮幹細胞可因應不同需要分化成特定的上皮細胞，如：皮膚、角膜、腸的軟組織等，每一種上皮細胞均是從上皮幹細胞經特定的終極轉化過程而形成，沒有能力再進一步按需要轉化成其他上皮細胞。因此，間質幹細胞和上皮幹細胞是不可互相替代的。

1 ClinicalTrials.gov. Accessed August 20, 2019.
2 Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.

間質幹細胞 (MSCs)

修復組織

  • 心血管疾病(例如：心肌修復)
  • 骨科應用(骨關節炎, 軟骨和肌腱修復)
  • 肺纖維化
  • 中風
  • 神經退行性疾病
    • 自閉症(ASD)
    • 阿爾茨海默氏病
    • 柏金遜症
    • 腦麻痹和癱瘓
    • 整體發展遲緩
  • 脊髓損傷
  • 肝衰竭引起的肝再生

輔助造血幹細胞(臍帶血)的移植

  • 縮短幹細胞被受贈者接受的時間
  • 減少免疫系統併發症

免疫系統調節12

  • 抗宿主疾病(GvHD)移植排斥作用13
  • 糖尿病: 甲型和乙型
  • 愛滋病
  • 克羅恩病
臍帶膜上皮幹細胞 (CLEpSCs)

傷口/軟組織修復

  • 上呼吸道疾病（例如：吸烟者的支氣管上皮的修復和再生）
  • 表面潰瘍（糖尿病）
  • 各種類型的燒傷17
  • 皮膚創傷
  • 皮膚傷口
  • 皮膚表皮重建18

器官再生

  • 肝23,24
  • 胰腺25,26
  • 胃腸道27,28

眼角膜19

  • 角膜皮樣瘤
  • 角膜疤痕和混濁
  • 角膜潰瘍
  • 乾眼症
  • 眼睛受傷（例如化學燒傷）
  • 角膜緣缺陷
  • 角膜緣不全症候群i
  • 黃斑部病變：
    • 年齡相關性近視
  • 斯塔加特黃斑營養不良
  • 眼表疾病
  • 翼狀胬肉
  • 史蒂文斯約翰遜症候群引起的眼部損傷

References

1 Chuang HM, Shih TE, Lu KY, et al. Mesenchymal Stem Cell Therapy of Pulmonary Fibrosis: Improvement with Target Combination. Cell Transplant. 2018;27(11): 15811587. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299195/
2 Wang F, Tang H, Zhu J, Zhang JH. Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke. Cell Transplant. 2018;27(12):1825-1834 https://www.ncbi.nlm.nih.gov/pubmed/30251564
3 Xue P, Wang M, Yan G. Mesenchymal stem cell transplantation as an effective treatment strategy for ischemic stroke in asia: a meta-analysis of controlled trials. Ther Clin Risk Manag. 2018; 14: 909928. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957058/
4 Shane, et al. Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction? Autism Open Access. 2015; 5(3) https://www.longdom.org/open-access/do-the-stem-cells-really-work-with-autism-spectrum-disorders-associatedwith-neuroimmune-interaction-2165-7890-1000151.pdf
5 Liu Q, Chen MX, Sun L, et al. Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders. World J Stem Cells. 2019; 11(2): 5572. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397804/
6 Siniscalco D, Kannan S, Semprn-Hern¡ndez N, et al. Stem cell therapy in autism: recent insights. Stem Cells Cloning. 2018; 11: 5567. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204871/
7 Xu P, Yang X. The Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Spinal Cord Injury Patients: A Meta-Analysis and Systematic Review. Cell Transplant. 2019; 28(1): 3646. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322141/
8 Alfaifi M, Eom YW, Newsome PN, et al. Mesenchymal stromal cell therapy for liver diseases. J Hepatol. 2018;68(6):1272-1285. https://www.ncbi.nlm.nih.gov/pubmed/29425678
9 Maria P. de Miguel, I. Prieto, et al. Mesenchymal Stem Cells for Liver Regeneration in Liver Failure: From Experimental Models to Clinical Trials. Stem Cells International. 2019:3945672 https://www.hindawi.com/journals/sci/2019/3945672/
10 Wang YH, Wu DB, Chen B, et al. Progress in mesenchymal stem cell–based therapy for acute liver failure. Stem Cell Research & Therapy. 2018;9(1):227 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109312/
11 Crippa S, Bernardo ME. Mesenchymal Stromal Cells: Role in the BM Niche and in the Support of Hematopoietic Stem Cell Transplantation. HemaSphere. 2018;2:6. https://journals.lww.com/hemasphere/Fulltext/2018/12000/Mesenchymal_Stromal_Cells__Role_in_the_BM_Niche.5.aspx
12 Damien P, Allan DS. Regenerative Therapy and Immune Modulation Using Umbilical Cord Blood-Derived Cells. Biol Blood Marrow Transplant. 2015;21(9):1545-54. https://www.bbmt.org/article/S1083-8791(15)00379-1/pdf
13 Zhao L, Chen S, Yang P, et al. The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease. Stem Cell Research & Therapy. 2019; 10: 182 https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1287-9
14 Clinical trials .Gov Website. Last accessed September 25, 2019 https://clinicaltrials.gov/ct2/results?cond=diabetes+mesenchymal+stem+cells&Search=Apply&recrs=b&recrs=a&recrs=f&recrs=d&recrs=e&age_v=&gndr=&type=&rslt=
15 Zhang Z, Fu J, Xu X, et al. Safety and immunological responses to human mesenchymal stem cell therapy in difficult-to-treat HIV-1-infected patients. AIDS. 2013; 27(8): 1283,1293 https://www.ncbi.nlm.nih.gov/pubmed/23925377
16 ClinicalTrials.org registry NCT01090817, NCT01157650, NCT01659762, NCT00294112, NCT00482092, NCT03901235, NCT03449069, NCT00543374, NCT03220243, NCT02445547. Last accessed September 25, 2019
17 ClinicalTrials.org registry NCT02904941, NCT03162367, NCT00856934, NCT00832156,NCT02145130, NCT03227146, NCT03229564, NCT02948023, NCT04030754, NCT03754218, NCT01655407, NCT02947737, NCT02765737, NCT00548314, NCT02325843, NCT03048188, NCT03913481, NCT02779205, NCT03791710, NCT02577861, NCT03686449. Last accessed September 25, 2019
18 Huang L, Wong YP, Gu H, et al. Stem cell-like properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy. 2011;13:14555. https://www.ncbi.nlm.nih.gov/pubmed/20735166
19 ClinicalTrials.org registry NCT00459290, NCT00841581, NCT03916679,NCT03687632,NCT03608293, NCT02586883, NCT01722656, NCT00003704, NCT00667641, NCT02573324, NCT01166763, NCT01376349, NCT00999531, NCT00335491, NCT03519178, NCT00291135, NCT01635231. Last accessed September 25, 2019
20 Clinical Trials website. https://clinicaltrials.gov/ct2/results?term=mesenchymal&age_v=&gndr=&type=Intr& . Last accessed September 8 2020.
21 Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.
22Afarid M, Sanie-Jahromi F. Mesenchymal Stem Cells and COVID-19: Cure, Prevention, and Vaccination. Stem Cells International 2021. 2021;0705:1-12
23Lim R, Hodge A, Moore G, et al. A Pilot Study Evaluating the Safety of Intravenously Administered Human Amnion Epithelial Cells for the Treatment of Hepatic Fibrosis. Front Pharmacol. 2017; 8:549.
24Lim RHG, Liew JXK, Wee A, et al. Safety Evaluation of Human Cord-Lining Epithelial Stem Cells Transplantation for Liver Regeneration in a Porcine Model. Cell Transplant. 2020 Jan-Dec; 29:963689719896559.
25Lebreton F, Lavallard V, Bellofatto K, et al. Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes. Nat Commun. 2019; 10, 4491.
26Zhou Y, Gan SU, Lin G, et al. Characterization of Human Umbilical Cord Lining-Derived Epithelial Cells and Transplantation Potential. Cell Transplantation. 2011; 20(11-12):1827-1841.
27Fujino A, Cuchimoto Y, Mori T, et al. Evaluation of safety and efficacy of autologous oral mucosa-derived epithelial cell sheet transplantation for prevention of anastomotic restenosis in congenital esophageal atresia and congenital esophageal stenosis. Stem Cell Res Ther. 2023; 14, 86.
28Kanetaka K, Eguchi S. Regenerative medicine for the upper gastrointestinal tract. Regenerative Therapy. 2020; 15, 129-137.


在全球各大學和研究機構利用間質幹細胞（MSCs）治療疾病的研究情況

疾病大學/研究機構名稱
抗宿主疾病美國堪薩斯大學醫學中心1
阿兹海默症三星首爾醫院2
腦麻痹美國杜克大學醫學中心3
慢性缺血性心肌病中國南京大學醫學院4
第一型糖尿病中國南京大學醫學院 5
越南胡志明萬漢綜合醫院6
第二型糖尿病越南胡志明萬漢綜合醫院 7
左心室功能障礙中國上海交通大學附屬第六人民醫院8
肝臟衰竭中國陝西西京消化病醫院9
骨關節炎印度尼西亞大學10
柏金遜症約旦大學11
類風濕性關節炎巴拿馬幹細胞中心12
中國西京醫院13
韓國全南大學醫院,
韓國江東慶熙大學醫院,
韓國建國大學醫院,
韓國慶熙大學,
SMG-SNU博羅前醫療中心,
南韓首爾大學14
脊髓受損西班牙巴塞隆納神經復健醫院15
膝關節骨關節炎中國山東聊城市人民醫院16
系統性紅斑狼瘡美國南卡羅來納醫科大學17

References

1 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03158896. Last accessed September 25, 2019.
2 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT02054208. Last accessed September 25, 2019.
3 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03473301. Last accessed September 25, 2019.
4 Clinical Trials website. https://ClinicalTrials.gov/show/NCT02635464. Last accessed September 25, 2019.
5 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT02763423. Last accessed September 25, 2019.
6 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03484741. Last accessed September 25, 2019.
7 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03943940. Last accessed September 25, 2019.
8 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03902067. Last accessed September 25, 2019.
9 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03668171. Last accessed September 25, 2019.
10 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03800810. Last accessed September 25, 2019.
11 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03684122. Last accessed September 25, 2019.
12 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT01985464. Last accessed September 25, 2019.
13 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03798028. Last accessed September 25, 2019.
14 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03618784. Last accessed September 25, 2019.
15 Clinical Trials website. https://clinicaltrials.gov/show/NCT03003364. Last accessed September 25, 2019.
16 Clinical Trials website. https://clinicaltrials.gov/show/NCT03166865. Last accessed September 25, 2019.
17 Clinical Trials website. https://clinicaltrials.gov/show/NCT02633163. Last accessed September 25, 2019.

在全球各大學和研究機構利用上皮細胞（CLEpSCs）治療疾病的研究情況

疾病 大學/研究機構名稱
皮膚傷口新加坡中央醫院燒傷中心
眼部表層肌肉衰竭新加坡眼部研究協會
日本京都府立醫科大學
持續性上皮缺損越南河内國立眼部協會

DCR No. 4525, Version C, January 2022.

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