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Cord Lining

Potential Applications of Umbilical Cord Lining Stem Cells

Potential Therapeutic Application

SourceUmbilical cord lining

Types of Stem Cells

Mesenchymal Stem Cells (MSCs)

Epithelial Stem Cells (EpSCs)

Potential Treatment for

Tissue repair

  • Cardiovascular diseases(e.g. Cardiac muscle repair)
  • Orthopaedic applications(Osteoarthritis, cartilage and tendon repair)
  • Pulmonary fibrosis
  • Stroke
  • Neurodegenerative diseases:
    • Autism spectrum disorder (ASD)
    • Alzheimer's disease
    • Parkinson's disease
    • Cerebral palsy and paralysis
    • Global developmental delay
  • Spinal cord injury
  • Liver regeneration from liver failure

Hscs Engraftment Support

  • Shorten time of engraftment
  • Reduce immune system complications

Immune modulation

  • Prevention and treatment of graft versus host disease (GvHD)
  • Diabetes: Type 1 and 2
  • HIV
  • Crohn’s disease

Wounds/soft tissue repair

  • Disorder of upper respiratory system
    (eg: Repair and regeneration of bronchial epithelium for smokers)
  • Surface ulcer (Diabetic)
  • Various types of burn
  • Tissue trauma
  • Skin wounds
  • Epidermal reconstitution

Organ Lining Regeneration

  • Disorder of upper respiratory system
    (eg: Repair and regeneration of bronchial epithelium for smokers)
  • Liver lining
  • Pancreatic lining
  • Gastrointestinal lining

Eye Conditions

  • Corneal dermoid
  • Corneal scars and opacities
  • Corneal ulcers
  • Dry eye syndromes
  • Eye injury (eg. Chemical burn)
  • Limbal deficiency
  • Limbal corneal insufficiency syndrome
  • Macular degenerative diseases:
    • Age related
    • Myopic
    • Stargardt's macular dystrophy
  • Ocular surface disease
  • Pterygium
  • Ocular damage due to stevens johnson syndrome

Today, more than 1000 clinical trials1 are on-going worldwide to uncover the potential of MSCs. Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications2.

Although there is evidence that MSC can change to certain types of EC (not stem cells), these cells cannot be changed into Epithelial Stem Cells (EpSC). The difference between EpSC and EC is that EpSC can differentiate into all different EC types such as skin, cornea, lining of the gut, etc. on demand. Whereas ECs have already reached terminal differentiation so these cells cannot be further differentiated into other EC types when needed. Thus, MSC and EpSC cannot be replaced by each other.

1. Accessed on 31 January 2019. (
2. Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.

MSC Clinical Trials – Global Institutions

DiseasesName of universities or research Institions
Stroke University Hospital, Grenobe, France
Spinal Cord Injury
  • Cairo University, Egypt
  • Chinese University of Hong Kong
Multiple Sclerosis
  • Spain-Carlos Health Institute
  • University of Cambridge, U.K.
  • Cleveland Clinic, U.S.
Amylotrophic Lateral Sclerosis Hadassah Medical Organization, Israel
Parkinson's Disease Jaslok Hospital and Research Centre, India
Multiple System Atrophy Yonsei University, South Korea
Liver Disease Cytori Therapeutics, U.S.
Diabetic Foot Ulcer
  • Third Military Medical University, China
  • Washington DC Veterans Medical Centre, U.S.
  • Ruhr-University Bochum, Germany
  • FuZhou General Hospital, China
  • Uppsala University, Sweden
Acute Graft Versus Host Disease University of Kansas Medical Center, United States
Alzheimer's Disease Samsung Medical Center, Korea
Cerebral Palsy Duke University Medical Center United States
Chronic Ischemic Cardiomyopathy Nanjing University Medical School, China
Rheumatoid Arthritis
  • Stem Cell Institute, Panama City, Panama
  • Xijing Hospital, China
  • Konkuk University Medical Center, Korea
  • Kyung Hee University Hospita, Korea
  • Seoul National University Hospital, Korea