Potential Applications of Umbilical Cord Lining Stem Cells
Potential Therapeutic Application
| Source | Umbilical cord lining | |
|---|---|---|
Types of Stem Cells |
Mesenchymal Stem Cells (MSCs) |
Epithelial Stem Cells (EpSCs) |
Potential Treatment for |
Tissue repair
Hscs Engraftment Support
Immune modulation
|
Wounds/soft tissue repair
Organ Lining Regeneration
Eye Conditions
|
Today, more than 1000 clinical trials1 are on-going worldwide to uncover the potential of MSCs. Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications2.
Although there is evidence that MSC can change to certain types of EC (not stem cells), these cells cannot be changed into Epithelial Stem Cells (EpSC). The difference between EpSC and EC is that EpSC can differentiate into all different EC types such as skin, cornea, lining of the gut, etc. on demand. Whereas ECs have already reached terminal differentiation so these cells cannot be further differentiated into other EC types when needed. Thus, MSC and EpSC cannot be replaced by each other.
1. ClinicalTrials.gov. Accessed on 31 January 2019. (http://www.clinicaltrials.gov/ct2/results?term=mesenchymal+stem+cells)
2. Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.
MSC Clinical Trials – Global Institutions
| Diseases | Name of universities or research Institions |
|---|---|
| Stroke | University Hospital, Grenobe, France |
| Spinal Cord Injury |
|
| Multiple Sclerosis |
|
| Amylotrophic Lateral Sclerosis | Hadassah Medical Organization, Israel |
| Parkinson's Disease | Jaslok Hospital and Research Centre, India |
| Multiple System Atrophy | Yonsei University, South Korea |
| Liver Disease | Cytori Therapeutics, U.S. |
| Diabetic Foot Ulcer |
|
| Diabetes |
|
| Acute Graft Versus Host Disease | University of Kansas Medical Center, United States |
| Alzheimer's Disease | Samsung Medical Center, Korea |
| Cerebral Palsy | Duke University Medical Center United States |
| Chronic Ischemic Cardiomyopathy | Nanjing University Medical School, China |
| Rheumatoid Arthritis |
|
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