Diseases Treated with Stem Cells and its Potential Applications

Diseases Treated with Stem Cells

Stem cells are at the forefront of one of the most fascinating and revolutionary areas of medicine today. Doctors recognize that stem cells have the potential to help treat numerous diseases by generating healthy new cells and tissue.

As a parent, you want to protect your family. At your baby’s birth, you have the unique opportunity to safeguard the health of the ones you love by storing your newborn child’s cord blood stem cells.

Stem cells in the blood of your baby’s umbilical cord have the potential to be used in the treatment of many diseases today. Stem cells could be used to treat haematopoietic and genetic disorders. In a cord blood transplant, stem cells are infused into a patient’s bloodstream where they go to work - healing and repairing damaged cells and tissue. With the successful engraftment of the stem cells, the patient’s blood and immune system are regenerated.

There are a wide range of diseases that are treatable with stem cells derived from cord blood and other sources of similar type of stem cells (Haematopoietic Stem Cell), like bone marrow and peripheral blood, including stem cell disorders, acute and chronic forms of leukemia, myeloproliferative disorders, and many more.

In addition to the host of conditions that can now be treated, it is the potential of stem cell treatments that holds the most excitement as research continues to uncover new possibilities. The potential and efficacy of treating diseases with stem cells are real.

Diseases Treated with Stem Cells

The following is a list of some of the diseases that have been treated with cord blood and other sources of similar type of stem cells (Haematopoietic Stem Cell), like bone marrow and peripheral blood. Stem cell therapies continue to change and evolve quickly.

BLOOD CANCERS

Leukaemia
  • Acute Biphenotypic Leukemia*
  • Acute Lymphoblastic Leukaemia*
  • Acute Myelogenous Leukaemia*
  • Acute Undifferentiated Leukemia*
  • Chronic Myelogenous Leukaemia*
  • Chronic Lymphocytic Leukemia*
  • Juvenile Myelomonocytic Leukemia*
  • Juvenile Chronic Myelogenous Leukemia (JCML)
Myeloproliferative Neoplasms
  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia
  • Essential Thrombocythemia
  • Polycythemia Vera
Myelodysplastic Syndromes
  • Refractory Anemia*
  • Refractory Anemia with Excess Blasts*
  • Refractory Anemia with Excess Blasts in Transformation*
  • Refractory Anemia with Ringed Sideroblasts (Sideroblastic anemia)*
  • Chronic Myelomonocytic Leukemia*
Other Blood Cancers
  • Multiple Myeloma
  • Plasma Cell Leukaemia
  • Waldenstrom's Macroglobulinemia
  • Histiocytic Neoplasms

SOLID TUMORS

  • Hodgkin Lymphoma*
  • Langerhans’ Cell Histiocytosis*
  • Neuroblastoma*
  • Non-Hodgkin Lymphoma*
  • Retinoblastoma
  • Medulloblastoma
  • Wilms Tumor

NON-MALIGNANT BLOOD DISORDERS

Anaemias
  • Aplastic Anaemia*
  • Congenital Dyserythropoietic Anaemia
  • Fanconi’s Anaemia*
  • Paroxysmal Nocturnal Hemoglobinuria
Hereditary Bone Marrow Failure Syndromes
  • Diamond-Blackfan Syndrome*
  • Dyskeratosis Congenita*
  • Pearson's Syndrome
  • Shwachman-Diamond Syndrome*
Inherited Red Cell Abnormalities Inherited Platelet Abnormalities
  • Amegakaryocytosis /Congenital Thrombocytopenia
  • Glanzmann's Thrombasthenia*

IMMUNE DISORDERS

Severe Combined Immune Deficiency (SCID)
  • Bare Lymphocyte Syndrome*
  • Omenn Syndrome*
  • Reticular Dysgenesis
  • Neutrophil Actin Deficiency
  • SCID with Adenosine Deaminase Deficiency (ADA-SCID)*
  • SCID which is X-linked*
  • SCID with absence of T & B Cells*
  • SCID with absence of T Cells, Normal B Cells*
Neutropenias
  • Kostmann Syndrome (Infantile Genetic Agranulocytosis)*
  • Myelokathexis*
Phagocyte Disorders
  • Chediak-Higashi Syndrome*
  • Chronic Granulomatous Disease*
Inherited Disorders of the Immune System & Other Organs
  • Cartilage-Hair Hypoplasia
  • Gunther’s Disease (Congenital Erythropoietic Protoporphyria)*
  • Systemic Mastocytosis*
Other Inherited Immune System Disorders
  • Common Variable Immunodeficiency*
  • DiGeorge Syndrome*
  • Evans Syndrome*
  • Hemophagocytic Lymphohistiocytosis
  • IKK Gamma Deficiency (NEMO Deficiency)*
  • IPEX Syndrome*
  • Leukocyte Adhesion Deficiency*
  • Wiskott-Aldrich Syndrome*
  • X-linked Lymphoproliferative Disease (Duncan’s syndrome)*
  • X-linked Hyper IgM Syndrome
  • Ataxia-Telangiectasia

METABOLIC DISORDERS

Leukodystrophy Disorders
  • Adrenoleukodystrophy*
  • Krabbe Disease*
  • Metachromatic leukodystrophy*
  • Pelizaeus-Merzbacher Disease
Lysosomal Storage Diseases
  • Alpha-Mannosidosis*
  • Gaucher’s Disease
  • Niemann-Pick Disease
  • Sandhoff Disease
  • Wolman Disease*
Mucopolysaccharidosis (MPS) Storage Diseases
  • Hunter Syndrome*
  • Hurler Syndrome*
  • Maroteaux-Lamy Syndrome*
  • Mucolipidosis II (I-cell Disease)*
  • Sanfilippo Syndrome*
  • Morquio Syndrome
  • Scheie Syndrome*
  • Sly Syndrome (beta-glucuronidase deficiency)
Other Metabolic Disorders
  • AL Amyloidosis
  • Lesch–Nyhan Syndrome*
  • Osteopetrosis*

The above is a list of some of the diseases that have been treated with cord blood and other sources of similar type of stem cells (Haematopoietic stem cells), like bone marrow and peripheral blood. Stem cell therapies continue to change and evolve quickly. Banking cord blood does not guarantee that the cells will provide a cure or be applicable in every situation. Use will be ultimately determined by the treating physician.

*Treated with cord blood stem cells

Clinical Trials

With the advancement of stem cell* research, the potential for future use of stem cell grows.

Below is a list of diseases currently under Clinical Trials. These are diseases for which stem cell* treatments appear to be beneficial, but have not been adopted as standard therapy. For some of these diseases, stem cell transplants only slow the progression of the disease, but do not produce a cure. For other diseases, stem cell treatments may help effect a cure, but further research is needed to determine the best candidate patients for stem cell therapy, the optimum stem cell dosage, the optimum method of cell delivery, etc.

For some patients, clinical research trials represent an avenue for receiving promising new therapies that would not otherwise be available. Patients with difficult to treat or currently "incurable" diseases, such as AIDS or certain types of cancer, may want to pursue participation in clinical research trials if standard therapies are not effective. Clinical research trials are sometimes lifesaving.

For the latest information, please visit www.clinicaltrials.gov

  • Alzheimer’s Disease*
  • Amyotrophic Lateral Sclerosis
  • Autism*
  • Brain Tumour
  • Cardiomyopathy
  • Cartilage repair
  • Cerebral palsy*
  • Cleft Palate Repair (Alveolar)
  • Compartment Syndrome
  • Critical Limb Ischemia
  • Crohn's disease
  • Diabetes Type 1*
  • Epidermolysis Bullosa*
  • Ewing Sarcoma
  • Graft-versus-Host Disease (GvHD)
  • Hearing Loss (acquired sensorineural)*
  • HIV*
  • Huntington’s Disease
  • Hypoplastic Left Heart Syndrome*
  • Hypoxic Ischemic Encephalopathy*
  • Ischemic Heart Disease
  • Ischemic Stroke
  • Kidney plus stem cell transplant
  • Liver cirrhosis*
  • Lupus
  • Multiple Sclerosi
  • Myocardial Infarction
  • Open cardiac surgery for congenital heart diseases
  • Ovarian Cancer
  • Parkinson’s Disease
  • Rhabdomyosarcoma
  • Rheumatoid Arthritis
  • Scleroderma
  • Spinal cord injury*
  • Testicular Tumour
  • Tissue Engineered Vascular Grafts for cardiac defects
  • Traumatic Brain Injury
  • Adrenoleukodystrophy
  • Chronic Granulomatous Disease (X-linked)
  • Fanconi Anemia
  • Metachromatic Leukodystrophy
  • Severe Combined Immunodeficiency X-linked (SCID-X1)
  • Severe Combined Immunodeficiency X-linked (ADA-SCID)
  • Sickle Cell
  • Thalassemia
  • Wiskott-Aldrich Syndrome
  • Bronchopulmonary Dysplasia (BPD)
  • Lysosomal Storage Diseases
Reference:


#The above is a list of some diseases that have been treated with cord blood and other sources of similar stem cells (haematopoietic stem cells), such as bone marrow and peripheral blood. Banking cord blood does not guarantee that the cells will provide a cure or be applicable in every situation. The use of stem cells will ultimately be determined by the treating physician.

*Treated with cord blood stem cells

DCR No.1286 siteUcb_v2
DCR No.1649 DiseaseList_v2_201803

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